Is it OK to say, `Irregardless of what you say, I plan to marry him’?

`Irregardless’ is a word that has caused a great deal of controversy. It has the same meaning as `regardless’; it is a word that is mostly used in informal contexts in America English. According to experts, it is a blend of `irrespective’ and `regardless’. The word is considered non-standard, and hence not all dictionaries include it. This is because the word `irregardless’ consists of two negatives; the prefix `ir’ means `not’, and the suffix `less’ means `without’. Avoid using the word.
Source: ‘Know Your English’ (The Hindu) – January 08, 2007